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Original Article
A Case of Congenital Hypothyroidism.
Woo Hyon Kwon, Soon Young Song, Chang Ho Han, Hyae Ri Chung, Soo Yong Kim, Young Dae Kwon
Clin Exp Pediatr. 1990;33(5):708-713.   Published online May 31, 1990
Recently, we experienced a case of congenital hypothyroidism in 3month-old girl, who came with chief complaints of prolonged jaundice for 2 months after birth. After admission, she was diagnosed congenital hypothyroidism by the laboratory tests, including biochemistry, radioimmunoassay, radioisotope study, and bony radiography, and since then treated with sodium-L-thyroxine orally. The case was presented with brief review of literatures.
Prognosis according to Etiology and Age at Diagnosis in Congenital Hypothyroidism.
Myoung Sook Nam, Young Jong Oh, Byung Hee Kim, Young Jong Woo, Young Youn Choi, Tai Ju Hwang
Clin Exp Pediatr. 1990;33(4):506-513.   Published online April 30, 1990
A retrospective study on patients with congenital hypothyroidism was undertaken. The following results were obtained from 17 patients, on whom follow up investigations were available. 1) Males outnumbered females. The etiologic classification revealed: thyroid agenesis (64.7%), dyshormonogenesis (23.5%), and ectopic thyroid (11.8%). 2) In two-thirds of cases the diagnosis were made under 1 year of age, with 23.5% of cases being diagnoses below 3 month and 41.2%...
A Case of Sexual Precocity with Congenital Hypothyroidism.
Wan Kyu Lee, Eun Jun Hyung, Duk Hi Kim
Clin Exp Pediatr. 1990;33(2):259-263.   Published online February 28, 1990
Sexual precocity in assocition with congenital hypothyroidism is a rare clinical entity. We experi- enced a case of sexual precocity, such as vaginal bleeding, breast development in a patient with congenital hypothyroidism' We present with the brief review of related literature.
Two Cases of Goitrous Hypothyroidism in Siblings.
Kwang Ok Lee, Hwa Il Kwag, Hoon Kook, Young Youn Choi, Tai Joo Hwang
Clin Exp Pediatr. 1990;33(1):129-134.   Published online January 31, 1990
The authors experienced two cases of goitrous hypothyroidism in siblings. The etiology was considered to be defect of iodide organification in steps of thyroxine synthesis. The diagnosis was made on the basis of history, clinical features, thyroid function test, thyroid scanning, ultrasonogram and perchlorate discharge test. We report these cases with a review of related literatres.
Two Siblings of Congenital Hypothyroidsm due to Organification Defect.
Young Kie Park, Kwang Sun Park, Byung Churl Lee
Clin Exp Pediatr. 1989;32(4):582-588.   Published online April 30, 1989
Congenital hypothyroidism due to a variety of defects in the biosynthesis of thyroid hormone is detected in 1/30,000-50,000 live births. In the iodide organification defect which is one of defect in the biosynthesis of thyroid hormone, iodide is not organified and may be rapidly discharged from the thyroid by administration of perchlorate. We experienced two siblings who had short stature, goiter, mental retardation, constipation and other...
Neurologic Outcome in Congenital Hypothyroidism.
Byeung Ju Jeoung, Duk Hi Kim, Chang Jun Coe, Hang Cho Kang
Clin Exp Pediatr. 1988;31(7):901-913.   Published online July 31, 1988
Congenital hypothyroidism is one of the most common endocrine disease in childhood and is a major cause of mental retardation. It is clear that the earlier treatment is started, the better intellec- tual potential and the likely absence of neurological sequellae. The present study was carried out to try to define the incidence and the nature of the neurologic disorders and to examine the...
Normal TSH Levels in Neonates by TSH Screening test.
Jae Won Song, Jong Lin Rhi, Sei Won Yang, Jung Hwan Choi, Chong Ku Yun, Hyung Ro Moon, Bo Youn Cho, Chang Soon Koh
Clin Exp Pediatr. 1988;31(6):754-761.   Published online June 30, 1988
In 110 term neonates without perinatal problems who were bom in SNUH, blood TSH levels were measured by TSH screening test for congenital hypothyroidism. The results are as follows 1) Normal TSH level was 14.8±7.8 µU/ml, 8.8±4.7 µU/ml, and 6.5±2.7 µU/ml in neonates of age 0 〜24 hours, 24—48 hours, and 48〜72 hours respectively, and all TSH values in neonates of age 48〜72 hours were...
The Effect of Thyroid Hormone Deficiensy on Growth Hormone Levels.
Duk Hi Kim, Chan Il Park
Clin Exp Pediatr. 1988;31(1):64-71.   Published online January 31, 1988
Growth hormone and thyroid hormone are known to affect growth and development. The present experiment was undertaken to assess GH levels in the serum and pituitary gland of prophylthiouracil (PTU) treated rats. The serum concentration of T4 were decreased during PTU treatment. Serum GH concentration and pituitary GH content were decresed with severity of hypothyroid status. After withdrawl of PTU, their levels were recovered gradually. Acidophil...
Clinical Study of Congenital Hypothyroidism.
Byung Churl Lee, Soon Joo Lee, Sung Hoon Cho
Clin Exp Pediatr. 1987;30(12):1401-1408.   Published online December 31, 1987
We reviewed 24 patients with congenital hypothyroidism to observe the etiology, clinical symptoms and signs, bone age, height age, the degree of mental retardation and growth velocity after treatment form Jan. 1983 to June 1987. The results were as follows: 1) The male to female ratio was about 1:3.8. The cases diagnosed under 1 year old were only 12.5%. 2) In etiologic classification, thyroid dysgenesis...
Case Report
3 Cases of Congenital Hypothyroidism.
Chul Hwan Park, Moo Young Oh, Tae Gyu Hwang, Soon Yong Lee, Yeon Soon Kim
Clin Exp Pediatr. 1987;30(3):320-326.   Published online March 31, 1987
We observed 3 cases of congenital hypothyroidism. A 43-day-old girl, a 372-month-old boy and a 5-year-old girl were presented. The causes were thyroid agenesis of case I, defective TSH receptor (suspect) of case II and undetermined in case III respectively. The diagnosis was made by clinical manifestations, thyroid function test, A brief review of literatures was made.
Original Article
Juvenile Chronic Lymphocytic Thyroiditis.
Duk Hi Kim
Clin Exp Pediatr. 1987;30(1):71-79.   Published online January 31, 1987
A diagnosis of chronic lymphocytic thyroiditis(CLT) was made in 90 children & adolescents according to Fisher’s criteria. The age of the group ranged between 4 years & 16 years. On the basis of serum T4, T3 & TSH, three groups of patients were distinguished at the time of diagnosis.: euthyroid group (n=49), hyperthyroid group (n=7), hypothyroid group (n=34), where three subgroups were classified;...
Case Report
A Case of Kocher-Debre-Semelaigne Syndrome.
Saeng Gu Cho, Song Tae Kim, Young Youn Choi, Tai Ju Hwang
Clin Exp Pediatr. 1985;28(11):1130-1135.   Published online November 30, 1985
The authors experienced a 9-year-old male patient with Kocher-Decre-Semelaigne syndrome, hypothyroidism with generalized muscular hypertrophy. He was admitted with puffy face, abdominal distension, retarded growth, mental retardation, generalized muscular hypertrophy and hypertonia. Thyroid function test revealed hypofunction and thyroid gland was not visualized by 99raTc scintiscan. The stigmas of hypothyroidism and the muscular hypertrophy disappeared promptly after synthyroid replacement. Muscular biopsy...
A Case Study of Conjenital Hypothyroidism.
Youn Suk Chung, Tae Sook Song, Ho Jin Park, Mi Ja Shin
Clin Exp Pediatr. 1985;28(3):283-287.   Published online March 31, 1985
Congenital hypothyroidism is one of the important causes of retardation of growth and development. A 4 year 2 month old male patient was admitted to our department of Pediatrics, who showed marked growth failure and developmental retardation. Congenital hypothyroidism was suspected by history and physical examination, and confirmed by thyroid function test and thyroid scan, which showed ectopic lingual thyroid. A brief...
Original Article
A Clinical Study on Thyroid Disease in Childhood.
Shin Chul Jun, Chan Yung Kim
Clin Exp Pediatr. 1984;27(6):592-602.   Published online June 30, 1984
The author summarized 287 cases of children who were diagnosed as having thyroid disease at Pediatric O.P.D. of the B.N.U. Hospital from Jan. 1973 to Aug. 1983. The children were grouped according to their thyroid function tests and the observed clinical data are as follows: 1)The ratio between male and female patients was 1 : 9.3. Age distribution was puberty,...
Case Report
A Case Study of Congenital Hypothyroidism Caused by Ectopic Thyroid.
Eui Soo Park, Sang Hee Cho, Gwi Jong Choi, Chong Moo Park, Suk Shin Cho
Clin Exp Pediatr. 1983;26(8):803-807.   Published online August 31, 1983
Congenital hypothyroidism can be caused by ectopic thyroid which classified as aberrant type and accesory type. The authors eyperienced a case, having congenital hypothyroidism caused by ectopic thyroid (lingual thyroid) which confirmed by abnormal physical findings, biochemical studies, radio- logical studies, radioisotope uptake test and thyroid scintigram, in 1 year and 7 months old age female patients with chief problems of growth retardation. A brief review...
A Case of 18p- Syndrome with Congenital Hypothyroidism.
Ji Young Kang, In Soon Lee, Woon Sik Kim
Clin Exp Pediatr. 1983;26(1):102-105.   Published online January 31, 1983
We have experienced a case of 18p- syndrome with congenital hypothyroidism in a 16-month-old girl who had microcephaly, flat nasal bridge, failure to thrive, left inguinal hernia and umbilical hernia. The diagnosis was confirmed by physical findings, cytogenetic study, thyroid function test and thyroid scanning. The review of the related literature was made briefly.
The Kocher-Debre-Semelaigne Syndrome.
M Y Chung, S I Kwon, S J Lee, D H Kum
Clin Exp Pediatr. 1982;25(1):92-96.   Published online January 31, 1982
A 4-year old girl with the Kocher-Debre-Semelaigne syndrome, hypothyroidism with generalized muscular hypertrophy is described. Histologic examination of a calf muscle showed musclular hypertrophy with focal eosinophilic degeneration. The stigmas of hypothyroidism and the muscular hypertrophy disappeared promptly and concomitantly following therapy with desiccated thyroid. Similar cases reported in literature are briefly reviewed. The clinical and histologic changes of the...
A Case of Athyrotic Cretinism.
Kyung Hae Park, Si Man Lee, Jong Woo Shin
Clin Exp Pediatr. 1981;24(11):1121-1126.   Published online November 15, 1981
A case of athyrotic cretinism in a four months old female infant was presented. Diagnosis was established by clinical feature, skeletal X-ray, biochemical studies, radio-isotope uptake test, and scintiscan. Pertinent literatures were also briefly reviewed.
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